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Midazolam, under the trade name Versed, among others, is a benzodiazepine medication used for anesthesia, procedural sedation, trouble sleeping, and severe agitation. buy midazolam online

Indications

Short-term management of insomnia. Conscious/Procedural sedation prior to or during diagnostic, therapeutic or endoscopic procedures such as dentistry, upper gastrointestinal endoscopy, bronchoscopy, cystoscopy, coronary angiography and cardiac catheterization, oncology procedures, radiologic procedures, suture of lacerations etc. buy midazolam online

And surgery performed under local anesthesia, either alone or in combination with other CNS depressants.

Premedication

• Induction of general anesthesia

• Sedation in intensive care

• Sedation in general anesthesia

• Status epilepticus.

Therapeutic Class

Benzodiazepine hypnotics, Benzodiazepine sedatives

Pharmacology

Midazolam/versed binds to stereospecific benzodiazepine receptors on the postsynaptic GABA neuron at several sites w/in the CNS, including the limbic system, reticular formation.

Enhancement of the inhibitory effect of GABA on neuronal excitability results by increased neuronal membrane permeability to Cl ions, which results in hyperpolarisation (a less excitable state) and stabilisation. Benzodiazepine receptors and effects appear to be linked to the GABA-A receptors.

Dosage & Administration

The duration of treatment with oral midazolam/ versed should not be more than of 2 weeks. In certain cases extension beyond the maximum treatment period may be necessary.

Insomnia:

• Adults: 7.5 mg to 15 mg daily (Oral)

• Elderly: 7.5 mg daily (Oral)

• Premedication: 7.5 mg to 15 mg, should be given 30-60 minutes before the procedure (Oral)

Endoscopic or Cardiovascular procedures:

• Adult: initial dose is 2.5 mg (IV)

• Elderly & debilitated patients: 1-1.5 mg (IV)

• Induction of Anesthesia: Adult: 10-15 mg (IV) or 0.07-0.1 mg/Kg body weight, usually 5 mg (IM)

• Children: 0.15-0.20 mg/Kg (IM)

• Elderly & debilitated patients: 0.025-0.05 mg/Kg (IM)

Rectal administration in children: for preoperative sedation, rectal administration of the ampoule solution is 0.35-0.45 mg/Kg, 20-30 min before induction of general anesthesia

Interaction

CNS depressants, erythromycin, azole type animycotics and cimetidine may interact with Midazolam.

Contraindications

Known hypersensitivity to versed or other benzodiazepines, severe respiratory insufficiency, severe hepatic insufficiency, sleep apnea syndrome, myasthenia gravis, patients with a history of alcohol or drug abuse and children. buy midazolam online

Side Effects

Drowsiness is the most common side effect. Less common side effects are CNS depression, ataxia, confusion, tiredness, muscle weakness, fatigue, headache, dizziness and double vision. These effects occur predominantly at the start of treatment and usually disappear with dose adjustment or continuation of therapy.

Pregnancy & Lactation

Insufficient data are available on versed to assess its safety during pregnancy. But benzodiazepines adversely affect the human fetus. So, their use should be avoided if there is safer alternative. Midazolam is excreted through breast milk. Therefore, Midazolam should not be used by the nursing mothers.

Precautions & Warnings

CNS depressants, erythromycin, azole type animycotics and cimetidine may interfere the metabolism of versed. So, caution should be taken during the concomitant treatment with these drugs along with Midazolam.

Long time use of versed may increase dependency. As versed is a strong sedative, it should not be taken before driving or other performance skilled tasks. buy midazolam online

Side Effects

Drowsiness is the most common side effect. Less common side effects are CNS depression, ataxia, confusion, tiredness, muscle weakness, fatigue, headache, dizziness and double vision. These effects occur predominantly at the start of treatment and usually disappear with dose adjustment or continuation of therapy. buy midazolam online

Contraindications

Known hypersensitivity to Midazolam or other benzodiazepines, severe respiratory insufficiency, severe hepatic insufficiency, sleep apnea syndrome, myasthenia gravis, patients with a history of alcohol or drug abuse and children.

Overdose Effects

versed should not be used more than the dosage guideline. Over dosage produces severe depression ranging from drowsiness to coma.

Storage Conditions

Protect from light and moisture, store in cool and dry place. Keep out of the reach of children.