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Jatenzo / Andriol (Testosterone Undecanoate) is used by men who have low or no testosterone due to certain medical conditions (such as hypogonadism).

Testosterone helps the body to develop and maintain male sexual characteristics (masculinity), such as a deep voice and body hair. Jatenzo Andriol 40 mg

Testosterone / Jatenzo also helps to maintain muscle and prevent bone loss, and is needed for natural sexual ability/desire.

Pharmacology

The effects of Jatenzo / testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors.

Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5α-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5α-reductase. Jatenzo Andriol 40 mg

The T-receptor or DHT-receptor complex undergoes a structural change that allows it to move into the cell nucleus and bind directly to specific nucleotide sequences of the chromosomal DNA.

The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.

Dosage

Testosterone Capsule: Usually, the dosage is 3-4 capsules daily during the first 2-3 weeks, followed by a gradual decrease to 1-3 capsules daily. You must take Testosterone with a meal. Swallow the capsules whole without chewing, using some water or other fluid. Jatenzo Andriol 40 mg

Take half of the daily dose in the morning and the other half in the evening.

If the daily dose is an uneven number of capsules, take the larger number in the morning.

If you have the impression that the effect of Testosterone is too strong or too weak, inform your doctor immediately.

Do not take a double dose to make up for forgotten individual dose.

When treatment with Testosterone is stopped, complaints as those before treatment may re-occur within a few weeks.

Administration

Food allows Jatenzo to be taken up by your body. Therefore, Testosterone must be taken with a meal.

Interaction

Other medicines may influence the effects of Jatenzo may affect other medicines. You must tell your doctor or pharmacist if you are using (or intend to use) rifampicin (an antibiotic) or medicines for epilepsy or sleeplessness. Jatenzo Andriol 40 mg

Contraindications

Hypercalcaemia or hypercalciuria, males with breast or prostate carcinoma. Pregnancy and lactation. Jatenzo Andriol 40 mg

Side Effects

Like all medicines, Jatenzo / Testosterone can have side effects.

In general: increased sexual desire, fluid retention in the tissues, usually marked by swelling of ankles or feet

In men: prolonged abnormal, painful erection of the penis, disturbed formation of sperm, decreased amount of sperm with seminal discharge

In elderly men: problems with passing urine

In young boys: early sexual development, erections occurring more often than normal, enlarged penis, disturbed growth

Tell your doctor as soon as possible if any side-effect becomes troublesome or continues.

Pregnancy & Lactation

Pregnancy Category X: Studies in animals or human beings have demonstrated foetal abnormalities or there is evidence of foetal risk based on human experience or both, and the risk of the use of the drug in pregnant women clearly outweighs any possible benefit. Jatenzo price

Precautions & Warnings

Extra supervision by a doctor is necessary in the treatment of young boys, since Testosterone suppletion may cause early sexual development and disturb growth. Jatenzo Andriol 40 mg

Medical checks may also be necessary in some other conditions. Therefore, tell your doctor if you have or have ever had heart disease, kidney disease, high blood pressure, epilepsy, migraine headaches, prostatic complaints, such as problems with passing urine

Driving and using machines: As far as is known Jatenzo have no adverse effect on alertness and concentration.

Overdose Effects

If you have taken several capsules at once, there is no need for great concern. However, you should consult your doctor. The oily substance in the capsule may cause diarrhea. Jatenzo Andriol 40 mg

Storage Conditions

Keep Jatenzo out of reach and sight of children. Store at 8°C-30°C. Store in the original package in order to protect from light. Do not use Jatenzo after the expiry date stated on the package, sachet and blister. Jatenzo Andriol 40 mg