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Modafinil | Provigil reduces extreme sleepiness due to narcolepsy and other sleep disorders, such as periods of stopped breathing during sleep (obstructive sleep apnea). buy Provigil online

It is also used to help you stay awake during work hours if you have a work schedule that keeps you from having a normal sleep routine (shift work sleep disorder).

Therapeutic Class: CNS stimulant drugs

Pharmacology

Modafinil is an indirect dopamine receptor agonist. This is the R-enantiomer of Modafinil which is a 1:1 mixture of the R- and S-enantiomers. Modafinil binds to the dopamine transporter and inhibits dopamine reuptake.

As a result, increases neuronal activity in the hypothalamus, enhances activity in hypothalamic wakefulness center (TMN, tuberomammillary nucleus) within the hypothalamic sleep wake switch. Modafinil 200 mg

Dosage & Administration

Adults:

• Obstructive Sleep Apnea (OSA) & Narcolepsy: 200 mg to 250 mg as a single dose in the morning.

• Shift Work Disorder (SWD): 200 mg as a single dose approximately 1 hour prior to the start of work shift.

Children: Safety and effectiveness in pediatric patients less than 17 years of age have not been established.

Elderly: In elderly patients, elimination of Provigil and its metabolites may be reduced because of aging. Therefore, consideration should be given to the use of lower doses and close monitoring in this population. Modafinil 200 mg

Interaction

The clearance of drugs that are substrates for CYP3A4 or CYP3A5 (e.g., steroidal contraceptives, Cyclosporine, Midazolam and Triazolam) may be increased by Modafinil which results in lower systemic exposure. Dosage adjustment of these drugs should be considered when used concomitantly with Provigil. Modafinil 200 mg

Elimination of drugs that are substrates for CYP2C19 (e.g., Phenytoin, Diazepam, Propranolol, Omeprazole and Clomipramine) may be prolonged by Modafinil which results in higher systemic exposure. Dosage adjustment of these drugs should be considered when used concomitantly with Modafinil.

More frequent monitoring of prothrombin times/ International normalized ratio (INR) should be considered whenever Modafinil is co-administered with Warfarin.

Caution should be used when concomitantly administering MAO inhibitors and Modafinil.

Contraindications

Contraindicated in patients with known hypersensitivity to Provigil or any of the excipients of this product

Side Effects

The most common side effects of Modafinil are serious rash, including Stevens-Johnson syndrome, angioedema and anaphylaxis reactions, multi-organ hypersensitivity reactions, persistent sleepiness, psychiatric symptoms and some cardiovascular events. Modafinil 200 mg

Pregnancy & Lactation

Pregnancy: There are no adequate and well controlled studies of Provigil in pregnant women. Modafinil should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: It is not known whether Provigil or its metabolites are excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Modafinil is buy Modafinil 200 mg

Precautions & Warnings

Patients should be cautioned about operating an automobile or other hazardous machinery until it is reasonably certain that Modafinil therapy will not adversely affect their ability to engage in such activities. Caution should be taken in treating patients with a history buy Provigil (Modafinil) online

Discontinuation of treatment should be considered if psychiatric symptoms develop. Increased monitoring of heart rate and blood pressure should be exercised. Caution should be exercised when prescribing Provigil to patients Modafinil 200 mg

Discontinuation of treatment should be considered if psychiatric symptoms develop. Increased monitoring of heart rate and blood pressure should be exercised. Caution should be exercised when prescribing Provigil Modafinil 200 mg

Use in Special Populations

Patients with hepatic impairment: In patients with severe hepatic impairment, Modafinil should be administered at a reduced dose.

Patients with renal impairment: There is inadequate information to determine safety and efficacy of dosing in patients with severe renal impairment.

Overdose Effects

There were no overdoses reported in the Provigil clinical studies. Symptoms of Modafinil overdose are likely to be like those of Modafinil which included excitation or agitation, insomnia and slight or moderate Modafinil 200 mg

There is no specific antidote for Provigil overdose. However, if overdose occurs, it should be managed with primary supportive care.

Storage Conditions: Store in a cool (below 25°C) and dry place protected from light.