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Indications

Suvorexant is indicated for the treatment of insomnia, characterized by difculties with sleep onset and/or sleep maintenance. buy belsomra online

Therapeutic Class

Miscellaneous sedatives & hypnotics

Pharmacology

Suvorexant / Belsomra 10 mg is a highly selective antagonist for orexin receptors OX1R and OX2R. The mechanism by which Suvorexant exerts its therapeutic efect in insomnia is presumed to be through antagonism of orexin receptors.

The orexin neuropeptide signaling system is a central promoter of wakefulness. Blocking the binding of wake-promoting neuropeptides orexin A and orexin B to receptors OX1R and OX2R is thought to suppress wake drive. buy belsomra online

Dosage & Administration

Recommended dose is 10 mg, no more than once per night taken before 30 minutes of going to bed, with at least 7 hours remaining before the planned time of awakening. If the 10 mg dose is well-tolerated but not effective, the dose can be increased, not to exceed 20 mg once daily. buy belsomra online

Lowest dose effective should be used for the patient. Time to effect may be delayed if taken with or soon after a meal.

Interaction

CNS-Active Drugs: An additive effect on psychomotor performance was observed when a single dose of 40 mg of Suvorexant was co-administered with a single dose of 0.7 g/kg alcohol. Suvorexant does not afect alcohol concentrations and alcohol does not afect Suvorexant concentrations.

effect s of Other Drugs on Suvorexant: Strong (e.g., ketoconazole or itraconazole) and moderate (e.g., diltiazem) CYP3A inhibitors signifcantly increased Suvorexant exposure. Strong CYP3A inducers (e.g., rifampin) substantially decreases Suvorexant exposure. buy belsomra online

effect s of Suvorexant on Other Drugs: Suvorexant is unlikely to cause clinically signifcant inhibition of human CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19 or CYP2D6. Chronic administration of Suvorexant is unlikely to induce the metabolism of drugs metabolized by major CYP isoforms.

Contraindications

Do not use in patients with narcolepsy.

Side Effects

Common side effects are Sleepiness during the day, Not thinking clearly, Act strangely, confused, or upset, Sleep-walking

Pregnancy & Lactation

Pregnancy Category C. There is no adequate and well-controlled studies in pregnant women. Suvorexant / Belsomra 10 mg should be used during pregnancy only if the potential beneft justifes the potential risk to the fetus. buy belsomra online

Precautions & Warnings

Before taking suvorexant, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

The effects of this drug can last even after you wake up the next day. If you did not get at least 7 hours of sleep or took other medications that made you sleepy or are more sensitive to this drug, you may feel alert but not think clearly enough to drive.

Alcohol or marijuana (cannabis) can also make you more sleepy. Wait at least 8 hours after taking this drug before driving, and do not drive, use machinery, or do anything that needs alertness until you can do it safely.

Avoid alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis). If you take the 20-milligram dosage of suvorexant / Belsomra 10 mg, do not drive, use machinery, or do anything that needs alertness the next day.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the side effects of this drug, especially confusion, unsteadiness, excessive drowsiness. Unsteadiness and drowsiness may increase the risk of falls.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if suvorexant passes into breast milk. Consult your doctor before breast-feeding.

Storage Conditions

Store in dry and cool place, protect from light & keep away from children.